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Hepatic damage caused by chronic arsenic toxicity in experimental animals

Clinically, NAC is used to support liver function, particularly as an antidote to acetaminophen (paracetamol) overdose, by replenishing glutathione and preventing toxin-induced liver injury

Most promising therapeutic approaches for BIPN have demonstrated efficacy primarily in rodent models, while their benefits in humans are still uncertain

Arch Biochem Biophys 237:408414 Cadenas E, Boveris A, Ragan CI, Stoppani AO (1977) Production of superoxide radicals and hydrogen peroxide by NADH-ubiquinone reductase and ubiquinol-cytochrome c reductase from beef-heart mitochondria

and the PS + CaOx group, in which cells were pretreated with PS-NPs for 24 h before exposure to 1.5 mM CaOx solution, with co-intervention lasting for 24 h